The Potential of Pineapple Crown (Ananas Comosus) as Removal of Kidney Stone

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Naimatul Khoiroh
Fatati Nurmala Sari
Aldi Gunawan
Anif Mega Hidayati
Siti Umrokah


Some people in Mojokerto use pineapple crowns as medicine to remove a kidney stones. However, research related to this topic is very limited, there is no specific data regarding the content of active substances in pineapple crown. So that in this study, kidney stone decay was tested with pineapple crown extract and analyzed the phytochemicals of pineapple crown were. The effect on the ability of pineapple crown to remove kidney stones was carried out in vitro by testing kidney stones obtained from one of the patients with kidney stone disease. The solubility of calcium oxalate which is the content of kidney stones was tested against pineapple crown extract with various solvents. While the phytochemical test was carried out 6 times on the extraction of pineapple crown with various solvent variations. From the results of tests carried out on the content of several phytochemical compounds such as saponins, tannins, flavonoids, triterpenoids, and steroids, it was found that the highest content was found in pineapple crown extract with water and ethanol solvents. From the in vitro test results of kidney stone solubility, it was found that there was an effect of pineapple crown on kidney stone solubility although it was not significant. The optimum concentration of pineapple crown extract from several variations of the concentration tested was 0.0625 M. Through this research, can provide scientific facts to the public about the use of pineapple crown extract for kidney stone removal.

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How to Cite
The Potential of Pineapple Crown (Ananas Comosus) as Removal of Kidney Stone. (2022). ALKIMIA : Jurnal Ilmu Kimia Dan Terapan, 6(1), 229-235.

How to Cite

The Potential of Pineapple Crown (Ananas Comosus) as Removal of Kidney Stone. (2022). ALKIMIA : Jurnal Ilmu Kimia Dan Terapan, 6(1), 229-235.


[1] K. Taguchi et al., “The Urological Association of Asia clinical guideline for urinary stone disease,” International Journal of Urology, vol. 26, no. 7. Blackwell Publishing, pp. 688–709, Jul. 01, 2019. DOI: 10.1111/iju.13957.
[2] J. Uribarri, “Chronic kidney disease and kidney stones,” Current Opinion in Nephrology and Hypertension, vol. 29, no. 2. Lippincott Williams and Wilkins, pp. 237–242, Mar. 01, 2020. DOI: 10.1097/MNH.0000000000000582.
[3] J. C. Lieske and X. Wang, “Heritable traits that contribute to nephrolithiasis,” Urolithiasis, vol. 47, no. 1. Springer Verlag, pp. 5–10, Feb. 05, 2019. DOI: 10.1007/s00240-018-1095-1.
[4] D. Zhang et al., “Urinary stone composition analysis and clinical characterization of 1520 patients in central China,” Scientific Reports, vol. 11, no. 1, Dec. 2021, DOI: 10.1038/s41598-021-85723-3.
[5] H. B. Widyasmara, P. Birowo, and N. Rasyid, "Urinary Stone Composition Analysis in Indonesian Population: A Single Major Centre Analysis," Indonesian Journal of Urology, vol. 25, no. 02, pp. 104–109, 2019.
[6] J. P. Ingimarsson, A. E. Krambeck, and V. M. Pais, “Diagnosis and Management of Nephrolithiasis,” Surgical Clinics of North America, vol. 96, no. 3. W.B. Saunders, pp. 517–532, Jun. 01, 2016. DOI: 10.1016/j.suc.2016.02.008.
[7] N. E. York, M. S. Borofsky, and J. E. Lingeman, “Risks associated with drug treatments for kidney stones,” Expert Opinion on Drug Safety, vol. 14, no. 12. Taylor and Francis Ltd, pp. 1865–1877, Dec. 02, 2015. DOI: 10.1517/14740338.2015.1100604.
[8] FAO, “Food and Agricultural Commodities Production. Food and Agricultural Organization of the United Nations-FAO, Rome.,” 2019.
[9] S. Dutta and D. Bhattacharyya, “Enzymatic, antimicrobial and toxicity studies of the aqueous extract of Ananas comosus (pineapple) crown leaf,” Journal of Ethnopharmacology, vol. 150, no. 2, pp. 451–457, Nov. 2013, DOI: 10.1016/j.jep.2013.08.024.
[10] J. B. Harborne, Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis, Third. London: Chapman & Hall, 1998.
[11] M. Y. Ghale-Salimi, M. Eidi, N. Ghaemi, and R. A. Khavari-Nejad, “Inhibitory effects of taraxasterol and aqueous extract of taraxacum officinale on calcium oxalate crystallization: In vitro study,” Renal Failure, vol. 40, no. 1, pp. 298–305, Oct. 2018, DOI: 10.1080/0886022X.2018.1455595.
[12] H. Nurhasnawati, R. Sundu, Sapri, R. Supriningrum, H. Kuspradini, and E. T. Arung, “Antioxidant activity, total phenolic and flavonoid content of several indigenous species of ferns in East Kalimantan, Indonesia,” Biodiversitas, vol. 20, no. 2, pp. 576–580, 2019, DOI: 10.13057/BIODIV/D200238.
[13] S. Morin Sinaga and M. Romarta Uly Hutabalian, “Indonesian Journal of Pharmaceutical and Clinical Research In Vitro Test of Anticalculi Effect from Ethyl Acetate Fraction of Chives Leaf (Allium schoenoprasum L.),” Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR), vol. 02, no. 2, pp. 20–23, 2019.
[14] X. Zeng, Y. Xi, and W. Jiang, “Protective roles of flavonoids and flavonoid-rich plant extracts against urolithiasis: A review,” Critical Reviews in Food Science and Nutrition, vol. 59, no. 13. Taylor and Francis Inc., pp. 2125–2135, Jul. 20, 2019. DOI: 10.1080/10408398.2018.1439880.
[15] D. Sansores-España et al., “Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms,” Molecules, vol. 27, no. 6. MDPI, Mar. 01, 2022. DOI: 10.3390/molecules27062008.