Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria)
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Published:
Aug 23, 2023
Keywords:
Anti-proliferative, curcumenol, demethoxycurcumin, germacrone, in-silico, white turmeric
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Abstract
Malignant disease or cancer progression burden the community after decades. This tumor formation or tumorigenesis involves cell proliferation. Protein Kinases (MAPK9s) is key proteins of regulating the growth and viability of cells physiologically and pathologically. Rhizomes of Curcuma zedoaria or zedoary or white turmeric is used as a health supplement. The aim of this study was to obtained candidate proteins for anti-proliferative using the docking method between the protein MAPK9 and the active compound obtained from the crude extract of white turmeric i.e. demethoxycurcumin, curcumenol and germacrone. The result s hows that complex MAPK-demethoxycurcumin have the lowest binding affinity -8.4 Kkal/mol, while MAPK-curcumenol was -8 Kkal/mol, and MAPK-Germacrone was -6.2 Kkal/mol, it determined the potential activity cell proliferation.
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Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria). (2023). Jurnal Biota, 9(2), 61-71. https://doi.org/10.19109/Biota.v9i2.13746
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How to Cite
Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria). (2023). Jurnal Biota, 9(2), 61-71. https://doi.org/10.19109/Biota.v9i2.13746
References
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Catanzaro, Michele, Emanuela Corsini, Michela Rosini, Marco Racchi, and Cristina Lanni. 2018. “Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea.” Molecules 23(11):1–17. https://doi.org/10.3390/molecules23112778
Chandrasekaran C, Velusami, Srinivasa Rao Boddapati, Srikanth Hongasandra Srinivasa, Edwin Jothie Richard, Joshua Allan Joseph, Murali Balasubramanian, and Amit Agarwal. 2013. “Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity.” BioMed Research International 2013. https://doi.org/10.1155/2013/158348
Dosoky, Noura S., and William N. Setzer. 2018. “Chemical Composition and Biological Activities of Essential Oils of Curcuma Species.” Nutrients 10(9):10–17. https://doi.org/10.3390/nu10091196
Ekawasti, Fitrine, Siti Sa’diah, Um Cahyaningsih, Ni Luh Putu Indi Dharmayanti, and Didik Tulus Subekti. 2021. “474Molecular Docking Senyawa Jahe Merahdan Kunyit Pada Dense Granules Protein-1Toxoplasma Gondii Dengan Metode In Silico.” Jurnal Veteriner 22(4):474–84. https://doi.org/10.19087/jveteriner.2021.22.4.474
Gonzalez, Hugo, Catharina Hagerling, and Zena Werb. 2018. “Roles of the Immune System in Cancer: From Tumor Initiation to Metastatic Progression.” Genes and Development 32(19–20):1267–84.
Hamdi A, Omer Abdalla, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, and Sri Nurestri Abd Malek. 2014. “Cytotoxic Constituents from the Rhizomes of Curcuma Zedoaria.” Scientific World Journal 2014. https://doi.org/10.1155/2014/321943
He D, Xiaoxia, Yongmin Xiong, Na Li and Can Jian. 2019. "Vaccines the History and Future, Chapter Vaccine Types". IntechOpen Limited: United Kingdom. https://www.intechopen.com/chapters/65813
Kaushik, Madan L, and Suni S Jalalpure. 2011. “Effect of Curcuma Zedoaria Rosc Root Extracts on Behavioral and Radiology Changes in Arthritic Rats.” Journal of Advanced Pharmaceutical Technology & Research 2(3):170. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217705/
Labh, Shyam Narayan, and Shubha Ratna Shakya. 2014. “Application of Immunostimulants as an Alternative to Vaccines for Health Management in Aquaculture.” International Journal of Fisheries and Aquatic Studies 2(1):153–56. https://doi.org/10.1111/j.1439-0426.1998.tb00641.x
Low, Heng Boon, and Yongliang Zhang. 2016. “Regulatory Roles of MAPK Phosphatases in Cancer.” Immune Network 16(2):85–98. https://doi.org/10.4110/in.2016.16.2.85
Manzoor, Zahid, Jung Eun Koo, and Young Sang Koh. 2014. “Mitogen-Activated Protein Kinase Signaling in Inflammation-Related Carcinogenesis.” Journal of Bacteriology and Virology 44(4):297–304. https://doi.org/10.4167/jbv.2014.44.4.297
Okda, Tarek M., Sary K. Abd-Elghaffar, Mohamed A. Katary, and Mohammad M. Abd-Alhaseeb. 2020. “Chemopreventive and Anticancer Activities of Indomethacin and Vitamin d Combination on Colorectal Cancer Induced by 1,2-Dimethylhydrazine in Rats.” Biomedical Reports 14(2):1–7. https://doi.org/10.3892/br.2020.1403
Prasetiawati, Riska, Meilia Suherman, Benny Permana, and Rahmawati Rahmawati. 2021. “Molecular Docking Study of Anthocyanidin Compounds Against Epidermal Growth Factor Receptor (EGFR) as Anti-Lung Cancer.” Indonesian Journal of Pharmaceutical Science and Technology 8(1):8. https://doi.org/10.24198/ijpst.v8i1.29872
Pua, Lesley Jia Wei, Chun Wai Mai, Felicia Fei Lei Chung, Alan Soo Beng Khoo, Chee Onn Leong, Wei Meng Lim, and Ling Wei Hii. 2022. “Functional Roles of JNK and P38 MAPK Signaling in Nasopharyngeal Carcinoma.” International Journal of Molecular Sciences 23(3). https://doi.org/10.3390/ijms23031108
Rita, Wiwik Susanah, I. Made Dira Swantara, and Ni Luh Sugiantini. 2019. “Anticancer Activity of Curcuma Zedoaria (Berg.) Roscoe Essential Oils against Myeloma Cells.” Proceedings of the Indonesian Chemical Society 1(1):23. https://doi.org/10.34311/pics.2019.01.1
Rivankar, Sangeeta. 2014. “An Overview of Doxorubicin Formulations in Cancer Therapy.” Journal of Cancer Research and Therapeutics 10(4):853–58. https://doi.org/10.4103/0973-1482.139267
Sari, Indah Wulan, Junaidin Junaidin, and Dina Pratiwi. 2020. “Studi Molecular Docking Senyawa Flavonoid Herba Kumis Kucing (Orthosiphon Stamineus B.) Pada Reseptor Α-Glukosidase Sebagai Antidiabetes Tipe 2.” Jurnal Farmagazine 7(2):54. https://dx.doi.org/10.47653/farm.v7i2.194
Srivastava, Sharad, Shanta Mehrotra, and A. K. S. Rawat. 2011. “Pharmacognostic Evaluation of the Rhizomes of Curcuma Zedoaria Rosc.” Pharmacognosy Journal 3(20):20–26. https://doi.org/10.5530/pj.2011.20.5
Sun, Yongchu, Kaihua Chen, Guoxiang Lin, Fangzhu Wan, Li Chen, and Xiaodong Zhu. 2021. “Silencing C-Jun Inhibits Autophagy and Abrogates Radioresistance in Nasopharyngeal Carcinoma by Activating the PI3K/AKT/MTOR Pathway.” Annals of Translational Medicine 9(13):1085–1085. https://doi.org/10.21037/atm-21-2563
Susanti, N. M. P., N. P. L. Laksmiani, N. K. M. Noviyanti, K. M. Arianti, and I. K. Duantara. 2019. “Molecular Docking Terpinen-4-Ol Sebagai Antiinflamasi Pada Aterosklerosis Secara in Silico.” Jurnal Kimia 221. https://doi.org/10.24843/JCHEM.2019.v13.i02.p16
Yu, Fangmiao, Kang He, Xiaoze Dong, Zhuangwei Zhang, Fenglei Wang, Yunping Tang, Yan Chen, and Guofang Ding. 2020. “Immunomodulatory Activity of Low Molecular-Weight Peptides from Nibea Japonica Skin in Cyclophosphamide-Induced Immunosuppressed Mice.” Journal of Functional Foods 68. https://doi.org/10.1016/j.jff.2020.103888
Zhang, Ailian, Xiumei Yang, Quanxiao Li, Yu Yang, Gan Zhao, Bin Wang, and Daocheng Wu. 2018. “Immunostimulatory Activity of Water-Extractable Polysaccharides from Cistanche Deserticola as a Plant Adjuvant in Vitro and in Vivo.” PLoS ONE 13(1):1–17. https://doi.org/10.1371/journal.pone.0191356
Zhang, Jianxing, Li Yuan, Sujie Wang, Jiang Liu, Huiqin Bi, Guojuan Chen, Jingjing Li, and Lili Chen. 2020. “Germacrone Protects against Oxygen-Glucose Deprivation/Reperfusion Injury by Inhibiting Autophagy Processes in PC12 Cells.” BMC Complementary Medicine and Therapies 20(1):77. https://doi.org/10.1186/s12906-020-2865-1
Zhong, Zhangfeng, Chi Teng Vong, Feiyu Chen, Horyue Tan, Cheng Zhang, Ning Wang, Liao Cui, Yitao Wang, and Yibin Feng. 2022. “Immunomodulatory Potential of Natural Products from Herbal Medicines as Immune Checkpoints Inhibitors: Helping to Fight against Cancer via Multiple Targets.” Medicinal Research Reviews 42(3):1246–79. https://doi.org/10.1002/med.21876