Identification of Anticancer Active Compound from GC-MS Test Results of Zodia Leaves (Evodia suaveolens) Ethanol Extract
Article Sidebar
Published:
Dec 5, 2019
Keywords:
antikanker, GC-MS, Zodia, Evodia suaveolens, Herbal
Main Article Content
Abstract
Cancer is estimated to be the second leading cause of death globally in 2018. The background of the study was the prevalence of cancer in Indonesia in 2018 reaching 775.120 people. Treatments such as surgery, chemotherapy, radiotherapy, immunotherapy, and hormone therapy have negative side effects. Herbal medicine is an alternative treatment with lower side effects that can reduce the side effects of existing treatments. The aim of this study was to identify the results of GC-MS active compounds from ethanol extract of zodia leaves which have the potential as anticancer. The method of this research was observational research through scientific literature. GC-MS results showed 22 active compounds contained in ethanol extract of zodia leaves. Based on the literature searching, there are 17 active compounds that have potential to be anticancer. Menthofuran; evodone; Bicyclopentene; Delta-Selinene; 3,5,7-Octatrien-2-Ol, 2,6-Dimethyl; Aromadendrene oxide 2; Alpha-bisabolol; 2,4-Dimethyl-2,4-Heptadienal; Phytol; Squalene; Beta-Tocopherol; D-alpha-Tocopherol; Stigmasta-5,23-dien-3.beta.-ol; (23S)-ethylcholest-5-en-3.beta.ol; 24,25-Dihydrolanosterol; Lanosterol; and Obtusifoliol. The compounds are targeted in breast, lung, and ovarian cancer.
Downloads
Download data is not yet available.
Article Details
How to Cite
Identification of Anticancer Active Compound from GC-MS Test Results of Zodia Leaves (Evodia suaveolens) Ethanol Extract. (2019). Jurnal Biota, 5(2), 89-95. https://doi.org/10.19109/Biota.v5i2.3374
Section
Artikel
Authors who publish with this journal agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
How to Cite
Identification of Anticancer Active Compound from GC-MS Test Results of Zodia Leaves (Evodia suaveolens) Ethanol Extract. (2019). Jurnal Biota, 5(2), 89-95. https://doi.org/10.19109/Biota.v5i2.3374
References
Bethune, G., Bethune, D., Ridgway, N., & Xu, Z. (2010). Epidermal Growth Factor Receptor (EGFR) In Lung Cancer: An Overview And Update. Journal of Thoracic Disease, 2(1), 48–51.
Brown, K. K., & Toker, A. (2015). The phosphoinositide 3-kinase pathway and therapy resistance in cancer. F1000Prime Reports, 7(February), 1–8. https://doi.org/10.12703/p7-13
Chabner, B. A., & Roberts, T. G. (2005). Chemotherapy and the war on cancer. Nature Reviews Cancer, 5(1), 65–72. https://doi.org/10.1038/nrc1529
Crandall, C. J., Sehl, M. E., Crawford, S. L., Gold, E. B., Habel, L. A., Butler, L. M., … Sinsheimer, J. S. (2009). Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. Breast Cancer Research, 11(4), 1–15. https://doi.org/10.1186/bcr2340
Darmapatni, K. A. G., Basori, A., & Suaniti, N. M. (2016). Pengembangan Metode GC-MS untuk Penetapan Kadar Acetaminophen pada Spesimen Rambut Manusia. 18(3). https://doi.org/10.20473/bsn.v18i3.3037
Ekins, S., Mestres, J., & Testa, B. (2007). In silico pharmacology for drug discovery: Applications to targets and beyond. British Journal of Pharmacology, 152(1), 21–37. https://doi.org/10.1038/sj.bjp.0707306
Fitrah, M., Winarno, H., & Simanjuntak, P. (2017). Isolasi dan Identifi kasi Senyawa Kimia Zat Anti Kanker dari Daun Kopasanda ( Chromolaena odorata ( L .)). Jurnal Ilmu Kefarmasian Indonesia, 15(1), 77–81.
Fitriatuzzakiyyah, N., Sinuraya, R. K., & Puspitasari, I. M. (2017). Cancer Therapy with Radiation: The Basic Concept of Radiotherapy and Its Development in Indonesia. Indonesian Journal of Clinical Pharmacy, 6(4), 311–320. https://doi.org/10.15416/ijcp.2017.6.4.311
Hamid, I. S., Sugiyanto, Meiyanto, E., & Widyarini, S. (2009). Ekspresi GST µ hepatosit terinduksi 7 , 12-dimetilbenz ( a ) antrasena dan pengaruh pemberian ekstrak etanolik Gynura procumbens CYP1A1 and GST µ expression of hepatocytes induced by 7 , 12-dimethylbenz ( a ) anthracene and the influence of. Indonesian Journal of Pharmacy, 20(4), 198–206.
Health, N. I. of. (2019). Cancer Treatment. Retrieved June 15, 2019, from https://www.cancer.gov/about-cancer/treatment
Inamura, K., Ninomiya, H., Ishikawa, Y., & Matsubara, O. (2010). Is the epidermal growth factor receptor status in lung cancers reflected in clinicopathologic features? Archives of Pathology and Laboratory Medicine, 134(1), 66–72.
Jiang, J., & Hu, C. (2009). Evodiamine: A Novel Anti-Cancer Alkaloid from Evodia rutaecarpa. Journal Molecules, 14, 1852–1859. https://doi.org/10.3390/molecules14051852
Ladanyi, M., & Pao, W. (2008). Lung adenocarcinoma: Guiding EGFR-targeted therapy and beyond. Modern Pathology, 21, S16–S22. https://doi.org/10.1038/modpathol.3801018
Lander, E. S. . L., Birren, L. M. ., Nusbaum, B., Zody, C., Baldwin, M. C. ., Devon, J., … McKernanKevin., P. (2001). Initial sequencing and analysis of the human genome. Nature, 409(April 2014), 860–921. Retrieved from https://www.researchgate.net/publication/233529681
Lisdawati, V. (2009). Kajian Terhadap Prospek Pengembangan Bahan Bioaktif Buah Mahkota Dewa [P. macrocarpa.] Sebagai Kandidat New Chemical Entity (NCE) untuk Pengobatan Kanker (Sitostatika). Bul. Penel. Kesehatan, 37(1), 23–32.
Muhamat, Wahyuni, T., Rusmiati, & Jumar. (2016). DAYA PROTEKSI MINYAK ATSIRI ZODIA ( Euvodia suaveolens ) DALAM BENTUK SPRAY TERHADAP TEMPAT HINGGAP NYAMUK Aedes aegypti L . DAN Culex quinquefasciatus. Prosiding Seminar Nasional Lahan Basah, (1), 278–282. Banjarbaru.
Mutiah, R. (2015). Evidence Based Kurkumin Dari Tanaman Kunyit (Curcuma longa) Sebagai Terapi Kanker Pada Pengibatan Modern. Jurnal Farma Sains, 1(1), 28–41.
Nurhayati, S., & Lusiyanti, Y. (2006). Apoptosis dan Respon Biologik Sel sebagai Faktor Prognosa Radioterapi. Bulettin Alara, 7(3), 57–66.
Organization, W. H. (2019). Cancer. Retrieved August 5, 2019, from https://www.who.int/cancer/en/
Radji, M., Aldiarti, H., Harahap, Y., & Irawan, C. (2010). Pengobatan Obat Herbal Pada Pasien Kanker Serviks.pdf. Jurnal Ilmu Kefarmasian Indonesia, 8(1), 33–39. Retrieved from http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/364/252
Ruswanto. (2015). Moleckular Docking Empat Turunan Isonicotinohydrazide Pada Mycobacterium tuberculosis Enoylscyl Carrier Protein Reductase (InhA). Jurnal Kesehatan Bakti Tunas Husada, 13(1), 135–141.
Sari, M. I., Wahid, I., & Suchitra, A. (2019). Tinjauan Pustaka Kemoterapi Adjuvan pada Kanker Kolorektal. Jurnal Kesehatan Andalas, 8(1), 51–57. Retrieved from http://jurnal.fk.unand.ac.id
Simaremare, E. S., Sinaga, D. I., & Agustini, V. (2017). Sabun Zodia Sebagai Repellent Terhadap Nyamuk Aedes aegypti. Jurnal Ilmu Kefarmasian Indonesia, 3(1), 11–16.
Suhud, F. (2015). Uji Aktivitas In-silico Senyawa Baru 1-Benzil-3-benzoilurea Induk dan Tersubstitusi sebagai Agen Antiproliferatif. Jurnal Farmasi Indonesia, 7(4), 242–251.
Brown, K. K., & Toker, A. (2015). The phosphoinositide 3-kinase pathway and therapy resistance in cancer. F1000Prime Reports, 7(February), 1–8. https://doi.org/10.12703/p7-13
Chabner, B. A., & Roberts, T. G. (2005). Chemotherapy and the war on cancer. Nature Reviews Cancer, 5(1), 65–72. https://doi.org/10.1038/nrc1529
Crandall, C. J., Sehl, M. E., Crawford, S. L., Gold, E. B., Habel, L. A., Butler, L. M., … Sinsheimer, J. S. (2009). Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. Breast Cancer Research, 11(4), 1–15. https://doi.org/10.1186/bcr2340
Darmapatni, K. A. G., Basori, A., & Suaniti, N. M. (2016). Pengembangan Metode GC-MS untuk Penetapan Kadar Acetaminophen pada Spesimen Rambut Manusia. 18(3). https://doi.org/10.20473/bsn.v18i3.3037
Ekins, S., Mestres, J., & Testa, B. (2007). In silico pharmacology for drug discovery: Applications to targets and beyond. British Journal of Pharmacology, 152(1), 21–37. https://doi.org/10.1038/sj.bjp.0707306
Fitrah, M., Winarno, H., & Simanjuntak, P. (2017). Isolasi dan Identifi kasi Senyawa Kimia Zat Anti Kanker dari Daun Kopasanda ( Chromolaena odorata ( L .)). Jurnal Ilmu Kefarmasian Indonesia, 15(1), 77–81.
Fitriatuzzakiyyah, N., Sinuraya, R. K., & Puspitasari, I. M. (2017). Cancer Therapy with Radiation: The Basic Concept of Radiotherapy and Its Development in Indonesia. Indonesian Journal of Clinical Pharmacy, 6(4), 311–320. https://doi.org/10.15416/ijcp.2017.6.4.311
Hamid, I. S., Sugiyanto, Meiyanto, E., & Widyarini, S. (2009). Ekspresi GST µ hepatosit terinduksi 7 , 12-dimetilbenz ( a ) antrasena dan pengaruh pemberian ekstrak etanolik Gynura procumbens CYP1A1 and GST µ expression of hepatocytes induced by 7 , 12-dimethylbenz ( a ) anthracene and the influence of. Indonesian Journal of Pharmacy, 20(4), 198–206.
Health, N. I. of. (2019). Cancer Treatment. Retrieved June 15, 2019, from https://www.cancer.gov/about-cancer/treatment
Inamura, K., Ninomiya, H., Ishikawa, Y., & Matsubara, O. (2010). Is the epidermal growth factor receptor status in lung cancers reflected in clinicopathologic features? Archives of Pathology and Laboratory Medicine, 134(1), 66–72.
Jiang, J., & Hu, C. (2009). Evodiamine: A Novel Anti-Cancer Alkaloid from Evodia rutaecarpa. Journal Molecules, 14, 1852–1859. https://doi.org/10.3390/molecules14051852
Ladanyi, M., & Pao, W. (2008). Lung adenocarcinoma: Guiding EGFR-targeted therapy and beyond. Modern Pathology, 21, S16–S22. https://doi.org/10.1038/modpathol.3801018
Lander, E. S. . L., Birren, L. M. ., Nusbaum, B., Zody, C., Baldwin, M. C. ., Devon, J., … McKernanKevin., P. (2001). Initial sequencing and analysis of the human genome. Nature, 409(April 2014), 860–921. Retrieved from https://www.researchgate.net/publication/233529681
Lisdawati, V. (2009). Kajian Terhadap Prospek Pengembangan Bahan Bioaktif Buah Mahkota Dewa [P. macrocarpa.] Sebagai Kandidat New Chemical Entity (NCE) untuk Pengobatan Kanker (Sitostatika). Bul. Penel. Kesehatan, 37(1), 23–32.
Muhamat, Wahyuni, T., Rusmiati, & Jumar. (2016). DAYA PROTEKSI MINYAK ATSIRI ZODIA ( Euvodia suaveolens ) DALAM BENTUK SPRAY TERHADAP TEMPAT HINGGAP NYAMUK Aedes aegypti L . DAN Culex quinquefasciatus. Prosiding Seminar Nasional Lahan Basah, (1), 278–282. Banjarbaru.
Mutiah, R. (2015). Evidence Based Kurkumin Dari Tanaman Kunyit (Curcuma longa) Sebagai Terapi Kanker Pada Pengibatan Modern. Jurnal Farma Sains, 1(1), 28–41.
Nurhayati, S., & Lusiyanti, Y. (2006). Apoptosis dan Respon Biologik Sel sebagai Faktor Prognosa Radioterapi. Bulettin Alara, 7(3), 57–66.
Organization, W. H. (2019). Cancer. Retrieved August 5, 2019, from https://www.who.int/cancer/en/
Radji, M., Aldiarti, H., Harahap, Y., & Irawan, C. (2010). Pengobatan Obat Herbal Pada Pasien Kanker Serviks.pdf. Jurnal Ilmu Kefarmasian Indonesia, 8(1), 33–39. Retrieved from http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/364/252
Ruswanto. (2015). Moleckular Docking Empat Turunan Isonicotinohydrazide Pada Mycobacterium tuberculosis Enoylscyl Carrier Protein Reductase (InhA). Jurnal Kesehatan Bakti Tunas Husada, 13(1), 135–141.
Sari, M. I., Wahid, I., & Suchitra, A. (2019). Tinjauan Pustaka Kemoterapi Adjuvan pada Kanker Kolorektal. Jurnal Kesehatan Andalas, 8(1), 51–57. Retrieved from http://jurnal.fk.unand.ac.id
Simaremare, E. S., Sinaga, D. I., & Agustini, V. (2017). Sabun Zodia Sebagai Repellent Terhadap Nyamuk Aedes aegypti. Jurnal Ilmu Kefarmasian Indonesia, 3(1), 11–16.
Suhud, F. (2015). Uji Aktivitas In-silico Senyawa Baru 1-Benzil-3-benzoilurea Induk dan Tersubstitusi sebagai Agen Antiproliferatif. Jurnal Farmasi Indonesia, 7(4), 242–251.