Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent
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Published:
Aug 31, 2020
Keywords:
Ointment Cymbopogon nardus Green sirih Zeolite Antibacterial
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Abstract
Lemongrass (Cymbopogon nardus L. Rendle) and green betel (Piper betle L.) plants are native to Indonesia. Empirically betel leaf can be used as a wound healer, lemongrass leaves are widely used as medicine for insect bites. On the basis of information obtained from various literatures, in this research has been done formulation of ointment from extract combination of lemongrass, green betel leaf and natural zeolite as antibacterial of Staphylococcus aureus. The use of zeolites based on features has a three-dimensional framework structure that is interconnected so that it has a large surface. Based on these reasons, it is believed that zeolites can increase the activity of active substances in ointments. The formulation of ointment extracts of lemongrass leaves-green betel leaves and zeolites with various dosages are KZ (zeolite control), KE (20% -5%), F1 (10% -6% + zeolite), F2 (20% - 5% + zeolite), F3 (30% -4% + zeolite), F4 (20% -0% + zeolite), F5 (0% -5% + zeolite) with a fixed amount of zeolite (2 gr). Evaluation of ointment preparations including organoleptic test, pH, homogeneity, spreading test and adhesion test showed results that met the requirements. The sample was tested for antibacterial activity with positive control (gentamicin 0.1%) showed that all formulas can provide an inhibition zone against staphylococcus aureus, except KZ. Test results were analyzed using One Way Annova with sig (0,000) <p value (0,050) followed by Tukey's further tests. From this explanation it can be concluded that the formulation of ointment from extract combination of lemongrass leaves, green betel leaves and zeolites has antibacterial agent.
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Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent. (2020). Jurnal Biota, 6(2), 92-99. https://doi.org/10.19109/10.19109/Biota.v6i2.6363
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How to Cite
Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent. (2020). Jurnal Biota, 6(2), 92-99. https://doi.org/10.19109/10.19109/Biota.v6i2.6363
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P. (2020). Formulasi Salep Ekstrak Buah Mengkudu (Morinda citrifolia L.) Kombinasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Staphylococcus aureus. Jurnal Pharmascience. (7)1; 9-17.
Neidrauer, M., Ecan U.K., Battharyya
A.,Samuels J., Sediak J.,Trikha R. (2014). Antimicrobial Efficacy and Wound Healing Property of Topical Ointment Containing Nitric-Oxide Loaded Zeolites. Journal of Medical Microbiology. 63(pt.2):203-209.
Voigt. (1995). Teknologi Farmasi Edisi V.
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Winato, BM., Sanjaya E., Siregar L., Fau
SKYMV., Mutia MS. (2019). Antibacterial Activity Of Serai Wangi Leaf Extract (Cymbopogon Nardus) Against Propionibacterium Acnes. BioLink Jurnal Biologi Lingkungan, Industri, Kesehatan. 6(1),50-58.
Zhang, QW., Lin, LG., Ye, WC (2018).
Techniques for Extraction and Isolation of Natural Products : a Comprehensive Review. Chinese Medicine, (13) 20, 1-55.
Ansel, H.C. (2008). Penghantar Bentuk Sediaan Farmasi, Edisi keempat. Jakarta: Universitas Indonesia Press.
Arif, Z. (2011). Karakterisasi dan Modifikasi Zeolit Alam sebagai Bahan Media Pendeteksi Studi Kasus: Kromium Heksavalen. Fakultas Matematika dan Ilmu Pengetahuan, Institut Pertanian Bogor.
Bhalodia, N.R., Shukla, V.J., (2011). Antibacterial and Antifungal Activities From Leaf Extracts of Casia fistula I. : An ethonomedical Plant. J. Adv. Pharm Technol Res. 2(2), 104-109.
Bhatia, VN and Barber RH. (1955). The
Effect of pH Variations of Ointment Bases on The Local Anesthetic Activity of Incorporated Ethyl Aminobenzoate *I. Hydrophilic Ointment U.S.P. Journal of The American Pharmaceutical Association (scientific ed.). 44(6), 342-343.
Cooper GM., Hausman RE. (2007). The
Cell : A Molecular Approach . 4th ed. Sunderland : Sinauer Associates, Inc.
Darmawi, Zakiyah H.M., Fahri P. (2013). Daya Hambat Getah Jarak Cina (Jatropha multifida L.) terhadap Staphylococcus aureus Secara In Vitro. Jurnal Medika Veterinaria. 7,113–115.
Difang, Z dan Chunsheng, X. (2019) : Study on the Application of Zinc-zeolite in Cosmetic Toothpaste. American Journal of Chemical Engineering, 7(2): 65-70, doi: 10.11648/j.ajche.20190702.12
Fitri Amalia. (2012). Formulasi Ekstrak
Kulit Buah Delima dan Daun Dewandaru Sebagai Antibakteri dan Penggunaan Zeolit untuk Menjaga Stabilitas Formula. (Tesis). Bogor. Insitut Pertanian Bogor.
Amalia F, Purwamargapratala Y. (2017).
Penggunaan Zeolit Untuk Stabilisasi Formula Ekstrak Kulit Buah Delima Sebagai Antibakteri. Jurnal Kimia dan Kemasan. 39(1), 25-30.
Ginting A.B., D. Anggraini, S. Indaryati, dan
R. Kriswarini. (2007). Karakterisasi Komposisi Kimia, Luas Permukaan Pori dan Sifat Termal dari Zeolit Bayah, Tasikmalaya, dan Lam-pung. Jurnal Teknik Bahan Nuklir. 3(1):1-48.
Greenwood D. (1995). Antibiotics
Susceptibility (Sensitivity) Test, Antimicrobial and Chemotheraphy. United State of America: Mc Graw Hill Company.
Subariyah, I., A. Zakaria, dan Y. Purwamargapratala. (2013). Karakterisasi Zeolit Alam Lampung Teraktivasi Asam Klorida dan Termodifikasi Asam Fosfat. Jurnal Teknologi Pengelolaan Limbah. 16 (3) ; 17-24.
Sunarintyas S, Widyastuti NH, Iman CW. (2006). Pengaruh Aktivasi Panas dan Penambahan Cu pada Zeolit Terhadap Daya Antimikroba Pada Staphylococcus aureus. Indonesian Journal of Dentistry. Edisi Khusus KPPIKG XIV.
Susanti, L., Wahidah, LK., Viogenta, P.
(2018). Optimasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Esktrak Buah Mengkudu (Morinda citrifolia L). Jurnal Farmasi Lampung (JFL), 7(2);60-67.
Susanti, L ., Wahidah, LK., Viogenta,
P. (2020). Formulasi Salep Ekstrak Buah Mengkudu (Morinda citrifolia L.) Kombinasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Staphylococcus aureus. Jurnal Pharmascience. (7)1; 9-17.
Neidrauer, M., Ecan U.K., Battharyya
A.,Samuels J., Sediak J.,Trikha R. (2014). Antimicrobial Efficacy and Wound Healing Property of Topical Ointment Containing Nitric-Oxide Loaded Zeolites. Journal of Medical Microbiology. 63(pt.2):203-209.
Voigt. (1995). Teknologi Farmasi Edisi V.
Yogyakarta: Gadjah Mada University Press;. 564, 3337, 382, 312 p. 1995.
Vifta RL., Wansyah PMA., Hati AK. (2017). Aktivitas antibakteri salep ekstrak etanol daun sirih hijau (Piper betle L.) Terhadap infeksi bakteri Staphylococcus aureus. Kartika Jurnal Ilmiah Farmasi, 5(2), 56-61.
Winato, BM., Sanjaya E., Siregar L., Fau
SKYMV., Mutia MS. (2019). Antibacterial Activity Of Serai Wangi Leaf Extract (Cymbopogon Nardus) Against Propionibacterium Acnes. BioLink Jurnal Biologi Lingkungan, Industri, Kesehatan. 6(1),50-58.
Zhang, QW., Lin, LG., Ye, WC (2018).
Techniques for Extraction and Isolation of Natural Products : a Comprehensive Review. Chinese Medicine, (13) 20, 1-55.