A Cream Formulation Of Extract Of Maja Leaves (Crescentia cujete) As An Antimicrobial Against Staphylococcus aureus
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Published:
Aug 23, 2021
Keywords:
Cream; Crescentia cujet; S aureus; Formulation
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Abstract
Maja (Crescentia cujete L) is a plant that has medicinal properties for various diseases. Leaves of Maja contain some compounds such which are thought to have the potential to be antibacterial. The purpose of this study was to determine the potential of maja leaf extract in cream dosage form and to prove the presence of Antibacterial activity against Staphylococcus aureus. The cream of Maja leaf extract was made into several formulations; (5, 10, 15 %) The results was the cream of Maja leaf extract was able to inhibit the growth of S. aureus with the largest inhibition zone at a concentration of 15% with an average of 11.52 ± 0.95mm. Cream formulations were evaluated physically; organoleptic was resulting F1 in brownish-green, F2 in brown, and F3 in dark brown. Homogeneity tests show that all formulations were homogeneous. The pH value of all formulations following the cosmetic standard was about 4.5 – 6.5. The standard viscosity value was between 2000 – 4000 cps. The stability test of cream preparations shows no changes in the form of low-temperature storage (4ºC), room temperature, and high temperature (40ºC), so that maja leaf extracts can be formulated in cream preparations and cream formulations
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A Cream Formulation Of Extract Of Maja Leaves (Crescentia cujete) As An Antimicrobial Against Staphylococcus aureus. (2021). Jurnal Biota, 7(2), 94-100. https://doi.org/10.19109/Biota.v7i2.7070
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How to Cite
A Cream Formulation Of Extract Of Maja Leaves (Crescentia cujete) As An Antimicrobial Against Staphylococcus aureus. (2021). Jurnal Biota, 7(2), 94-100. https://doi.org/10.19109/Biota.v7i2.7070
References
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Hartati, H., Suryani, I., Putri, S. E., & Hasyim, M. (2017). Uji Aktivitas Antimikroba Ekstrak Daun Crescentia cujete L terhadap Staphylococcus aureus, Escherichia coli dan Candida albicans. Prosiding Seminar Nasional LP2M UNM, 425–427. http://103.76.50.195/semnas lemlit/article/view/4056
Hasanah, U., Rosdiana, D., & Syaefudin, S. (2017). Antibacterial Activity of Ethanol Extract from Stem Bark and Leaves of •Berenuk (Crescentia cujete L.). Current Biochemistry, 4(1), 1–14. https://doi.org/10.29244/cb.4.1.1-14
More, B. H., Sakharwade, S. N., Tembhurne, S. V., & Sakarkar, D. M. (2013). Evaluation of Sunscreen activity of Cream containing Leaves Extract of Butea monosperma for Topical application. International Journal of Research in Cosmetic Science, 3(1), 1–6.
Pandey, A., Jagtap, J. V., Patil, A. A., Joshi, R. N., & Kuchekar, B. S. (2010). Formulation and evaluation of anti- bacterial and anti-fungal activity of a herbal ointment containing Aloe- vera, Azadirachta indica and Curcuma- longa. Journal of Chemical and Pharmaceutical Research, 2(3), 182–186. https://www.jocpr.com/archive/jocpr-volume-2-issue-3-year-2010.html
Sonia, S., Kumari, H. L. J., Ruckmani, K., & Sivakumar, M. (2017). Antimicrobial and antioxidant potentials of biosynthesized colloidal zinc oxide nanoparticles for a fortified cold cream formulation: A potent nanocosmeceutical application. Materials Science & Engineering C, 79, 581–589. https://doi.org/10.1016/j.msec.2017.05.059
Ardianti, A., & Kusnadi, J. (2014). Ekstraks Antibakteri dari Daun Berenuk (Crescentia cujete Linn.) Menggunakan Metode Ultrasonik. Jurnal Pangan Dan Agroindustri, 2(2), 28–35. https://jpa.ub.ac.id/index.php/jpa/article/view/34
Azubuike, C. P., Ejimba, S. E., Idowu, A. O., & Adeleke, I. (2015). Formulation and Evaluation of Antimicrobial Activities of Herbal Cream Containing Ethanolic Extracts of Azadirachta indica Leaves and Aloe Vera Gel. Journal of Pharmacy and Nutrition Sciences, 5(2), 137–142. http://dx.doi.org/10.6000/1927-5951.2015.05.02.6
Chen, M. X., Alexander, K. S., & Baki, G. (2016). Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application. Journal of Pharmaceutics. https://doi.org/10.1155/2016/5754349
Das, N., Islam, M. E., Jahan, N., Islam, M. S., Khan, A., Islam, M. R., & Parvin, M. S. (2014). Antioxidant activities of ethanol extracts and fractions of Crescentia cujete leaves and stem bark and the involvement of phenolic compounds. BMC Complementary and Alternative Medicine, 14(1), 1–9. https://doi.org/10.1186/1472-6882-14-45
Departemen Kesehatan RI. (2000).Parameter Standar Umum Ekstrak Tumbuhan Obat (Pertama). Departemen Kesehatan RI. Depkes RI. (1995). Farmakope Indonesia. Edisi IV. Departemen KesehatanRepublik Indonesia.
Dewi, M. K., Ratnasari, E., & Trimulyono, G. (2014). Aktivitas Antibakteri Ekstrak Daun Majapahit (Crescentia cujete) terhadap Pertumbuhan Bakteri Ralstonia solanacearum Penyebab Penyakit Layu. LenteraBio: Berkala Ilmiah Biologi, 3(1), 51–57. https://jurnal mahasiswa.unesa.ac.id/index.php/le nterabio/article/view/7090
Ejelonu, B., Lasisi, A., Olaremu, A., & Ejelonu, O. (2011). The chemical constituents of calabash (Crescentia cujete). African Journal of Biotechnology, 10(84), 19631–19636. https://doi.org/10.5897/ AJB11.1518
Gustomi, G., Nurusman, L., & Susilo, S. (2018). Pengaruh Pemberian Mikroorganisme Lokal (MOL) Rebung Bambu Surat (Gigantochloa vesticillata (Willd.) Munro) terhadap Pertumbuhan Bayam Merah (Amaranthus tricolor L.). Bioeduscience, 2(1), 81–87. https://doi.org/10.29405/j.bes/2181-871336
Hartati, H., Suryani, I., Putri, S. E., & Hasyim, M. (2017). Uji Aktivitas Antimikroba Ekstrak Daun Crescentia cujete L terhadap Staphylococcus aureus, Escherichia coli dan Candida albicans. Prosiding Seminar Nasional LP2M UNM, 425–427. http://103.76.50.195/semnas lemlit/article/view/4056
Hasanah, U., Rosdiana, D., & Syaefudin, S. (2017). Antibacterial Activity of Ethanol Extract from Stem Bark and Leaves of •Berenuk (Crescentia cujete L.). Current Biochemistry, 4(1), 1–14. https://doi.org/10.29244/cb.4.1.1-14
More, B. H., Sakharwade, S. N., Tembhurne, S. V., & Sakarkar, D. M. (2013). Evaluation of Sunscreen activity of Cream containing Leaves Extract of Butea monosperma for Topical application. International Journal of Research in Cosmetic Science, 3(1), 1–6.
Pandey, A., Jagtap, J. V., Patil, A. A., Joshi, R. N., & Kuchekar, B. S. (2010). Formulation and evaluation of anti- bacterial and anti-fungal activity of a herbal ointment containing Aloe- vera, Azadirachta indica and Curcuma- longa. Journal of Chemical and Pharmaceutical Research, 2(3), 182–186. https://www.jocpr.com/archive/jocpr-volume-2-issue-3-year-2010.html
Sonia, S., Kumari, H. L. J., Ruckmani, K., & Sivakumar, M. (2017). Antimicrobial and antioxidant potentials of biosynthesized colloidal zinc oxide nanoparticles for a fortified cold cream formulation: A potent nanocosmeceutical application. Materials Science & Engineering C, 79, 581–589. https://doi.org/10.1016/j.msec.2017.05.059